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During the 7th century, most of the Balkans were overrun by Slavic invasions, which left only the fortified towns and the coasts in the hands of the Greek-speaking Byzantine Empire.
"Macedonia" was then used for a new theme in the late 8th century under Irene of Athens.
Thereafter Macedonia remained under Byzantine control until the Fourth Crusade (1204).Its extent beyond the center varied; some Macedonian kings could not hold their capital; Philip II expanded his power until it reached from Epirus, across Thrace to Gallipoli, and from Thermopylae to the Danube.His son Alexander the Great conquered most of the land in southwestern Asia stretching from what is currently Turkey in the west to parts of India in the east.The borders of each of these entities were different.It was centered on the fertile plains west of the Gulf of Salonica (today north-western Greece); the first Macedonian state emerged in the 8th or early 7th century BC.
The contemporary geographical region of Macedonia is not officially defined by any international organisation or state.